Heme might be one of those things from biochem that you learned, vaguely remember something about 4 things holding iron, and then didn’t think about again.
Recent evidence suggests that it is also involved in signaling!
This group did something super smart with a photoaffinity probe to enrich interactors —
— and, darned if it don’t like heme has a bunch of protein interactions. Really cool approach that raises some interesting fundamental questions about what can and should be considered a signaling molecule!
